Endocrine Disorders Term Paper Example | Topics and Well Written Essays - 750 words

Endocrine Disorders - Term Paper Example In some diseases abnormalities occur in the gland which cause irregularity in the secretion of these thyroid hormones. The most common abnormalities of thyroid gland are hyperthyroidism and hypothyroidism. Hyperthyroidism means the excessive secretion of thyroid hormones from thyroid gland whereas Hypothyroidism is the decreased secretion of thyroid hormone from thyroid gland. ETIOLOGY Graves disease is an autoimmune disease whereas Myxedema is a disease caused by hypothyroidism. In autoimmune diseases our immune system produces antibodies against our own organs or organ system. In Graves disease our immune system produces antibodies against thyroid gland which increase the secretion of the thyroxine from thyroid gland. These antibodies are called thyroid stimulating immunoglobulin (TSI). Thyroid stimulating immunoglobulins bind to the receptor and imitate the action of thyroid stimulating hormone in releasing thyroxine from the thyroid gland. The effect of thyroid stimulating immuno globulin is excessive and causes increased production and secretion of thyroxine from the thyroid gland. Another type of immunoglobulin that is formed by our immune system against the thyroid gland also acts on the TSH receptors and stimulates the growth of thyroid gland excessively. These immunoglobulins are known as thyroid growth stimulating immunoglobulins (TGI). These antibodies are the primary cause because of which Graves Disease occurs in an individual. Myxedema on the other hand is a condition caused by hypothyroidism and not hyperthyroidism which is seen patients with Graves Disease. The reason for which edema occurs in hypothyroidism is not clearly known but it is said that the increased deposition of chondrioton sulphate and hyaluronic acid in interstitial spaces causes it. The causes of hypothyroidism that eventually lead to myxedema are autoimmune diseases, thyroiditis or surgically removed thyroid gland. In other words Myxedema is a condition caused by lack of thyroid hormones whereas Graves Disease itself leads to excess activity of the thyroid gland. Myxedema and Graves Disease are both concerned with the abnormality of the thyroid gland. SYMPTOMS The patients suffering from Graves disease show diffuse hyperplasia of thyroid, anxiety and tremor of hands. The patient also loses weight and suffers from muscle weakness. The patient will experience extreme fatigue but will be unable to sleep properly. The skin of the patient will be soft and warm. Intolerance to heat and extreme sweating are also seen in the patients suffering from Graves disease. Increased gastrointestinal tract motility also occurs which leads to mal-absorption of food and diarrhea. Exophthalmos is also seen in these patients which is the protrusion of eyeball. The patients with myxedema on the other hand show sluggishness in mental and physical activity. The patients suffering from myxedema show difficulty in speech and intolerance to cold. Sympathetic activity is decreased whi ch in turn decreases the gastrointestinal motility and sweating. The decreased gastrointestinal motility in turn causes constipation. Due to decreased sympathetic activity the blood flow in these patients is low and so the patients looks pale. These patients have coarse facial features and enlarged tongue. The voice becomes deep in myxedema. TREATMENT In Graves disease the

Managing Financial Principles and Techniques Essay

Managing Financial Principles and Techniques - Essay Example For this project the company has hired an international firm of management consultants who has forecasted the cost of production, selling price and profit per unit for mobile. They have also forecasted the demand for the new mobile in 5 year period down the line. The forecast made by them is as follows- Net Present value (NPV) is very common financial tool often used by the management to find out whether a new project will be beneficial in the future or not. NPV is the â€Å"difference between the present value of cash inflows and the present value of cash outflows† (Investopedia. 2009). The major advantage of this tool is that it takes time value of money into account, thus the result arrived at are more accurate as compared to simple pay back value. But many people find if a bit complicated (Stoltz, A. & Viljoen, M. 2007). The company assumes that per unit fixed cost and interest per unit, both varies with the level of production. But other general costs like advertising expenditure and maintenance remain constant, irrespective to the level of production. As per the result derived from the analysis it is found that the NPV of the project is negative, hence the project should not be accepted. The company has an option that instead of setting the new production line, they can use the existing machine which is under utilized. As per the company’s policy the machinery has to be depreciated along straight line method, so next year the written down value will become zero. Thus in the second year company has to purchase a new machine which will cost  £500,000. Thus the NPV and the IRR of the project will be as follows- The NPV of the project comes positive which indicates that the project will have sufficient cash inflow and it will be profitable in the long term. Hence on the basis of NPV the project can be accepted. The IRR of the project is 35%; which is above the cost of capital (10%). So this clearly indicates that the project should be